TranspariMED clinical trial transparency

2 Jul 2020

A coalition of 21 European health and patient groups today called on medical research institutions across the continent to make the results of their clinical trials public.

Letters sent to 56 major institutions – most of them universities and hospitals – flag their current weak performance, and ask them to explain what steps they are taking to clear their backlogs of missing tri...

25 Jun 2020

The Spanish national clinical trial registry is riddled with holes, a report released today warns. Results are verifiably missing for 122 trials, in violation of a Spanish law that requires companies and institutions running trials to upload results within a year of completing a trial.

The true number of overdue missing results is likely to be far higher, because registry entrie...

23 Jun 2020

Numerous clinical trials involving children are missing results from the European trial registry, data released by the European Medicines Agency (EMA) shows.

UPDATE 26 June: The European Medicines Agency today got in touch to challenge the figures reported in the original version of this blog. The blog below has been amended to take this new information into account. Please see...

17 Jun 2020

The results of over half of COVID drug trials currently being run in Europe are at high risk of becoming research waste, a TranspariMED report released today shows.

Out of 118 clinical trials of potential drug treatments, 79 trials are being run by companies and institutions that have no experience of uploading results onto the European clinical trial registry.

This means that th...

12 Jun 2020

In recent years, numerous universities and NHS Trusts across the UK have significantly improved their reporting of the results of drug trials.

However, it appears that at many leading institutions, these laudable efforts have not been extended to trials of medical devices, which often are of equal or even greater importance to patients.

In early April, TranspariMED filed Freedom...

10 Jun 2020

The UK’s medicines regulator MHRA is refusing to publicly identify clinical trials in which serious breaches of the protocol or Good Clinical Practice rules have been detected.

The MHRA is responsible for monitoring compliance with these rules in clinical trials of drugs in order to provide “assurance that the rights, safety and well-being of subjects are protected and that the...

4 Jun 2020

The FDA has failed to collect over $10 billion in fines from companies and universities for violations of a key clinical trial transparency law, data released today show. 

According to the latest FDAAA Trials Tracker figures, 2,050 clinical trials are currently missing results on the world’s largest trial registry, ClinicalTrials.gov, which was set up to provide a comprehensive...

3 Jun 2020

Over 40% of clinical trials of drugs currently being examined as possible treatments for COVID-19 have not made their results public, leaving important evidence gaps for the safety of drugs being repurposed for coronavirus patients, a study published today shows

A team of researchers found that out of 3,754 completed trials involving 19 different drugs, 1,516 trials have made...

2 Jun 2020

A study published today warns that getting a comprehensive overview of Covid-19 clinical trials is difficult due to flawed clinical trial registrations and weaknesses in the global trial registry infrastructure.

The 'living systematic review' by the Infectious Diseases Data Observatory (IDDO) analyses all Covid studies listed on trial registries as of early April 2020. It covers...

22 May 2020

German universities have uploaded the results of 76 clinical trials over the past six months. Universities have uploaded twice as many results over the past six months than during the preceding six years combined.

In December 2019, TranspariMED and BUKO Pharma-Kampagne released a report showing that German universities had a very weak track record in clinical trial publication.

I...

14 May 2020

A coalition of health groups has called on the European Medicines Agency to make public the full evidence on Covid-19 drugs as rapidly as possible.

In an open letter published today, four national Cochrane groups and IQWIG call for the publication of the Clinical Study Reports for all COVID-19 medicines and vaccines on the day a European marketing authorisation is issued....

12 May 2020

A new manual aims to assist universities across Europe in making their clinical trial results public.

It provides practical, step-by-step guidance on how to meet EU regulatory requirements and adopt WHO best practices, drawing on the experiences of successful universities in six European countries.

NOTE: Hyperlinks did not work In the version of the manual that was originally up...

11 May 2020

Evidence gaps on drugs are undermining the ability of scientists to identify potential treatments for COVID-19, scientists warn.

A review of clinical trials for favipiravir, a drug that may hold promise as a COVID-19 treatment, found that 12 out of the 14 trials completed worldwide do not have results available on trial registries.

These trials tested favipiravir for other indica...

24 Apr 2020

Over 500 clinical trials of potential COVID-19 treatments and interventions have been launched worldwide.

Here's a quick guide to getting data on who is researching what, where and when - and what they have discovered.

A more comprehensive overview is available for download below.

COVID-evidence now launched 

A living database of trials on interventions for COVID-19 focusing on agg...

24 Apr 2020

FDA secrecy surrounding falsification of data or violations in adverse event reporting detected during clinical trials is undermining the integrity of the scientific evidence base on drugs and medical devices, experts warn.

Writing in JAMA, they note that inspection reports compiled by the U.S. Food and Drug Administration are often kept from the medical research community,...

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