American academic organisations have significantly increased resources devoted to improving compliance with clinical trials registration and results reporting requirements, a new study  shows.   The authors note that these investments have been paralleled by a strong increase in many universities’ compliance with legal clinical trial transparency requirements. Over the course of six years, the proportion of U.S. organisations with clinical trial registration policies increased to 74%, while...

The PATHWAYS trial of puberty blockers for transgender youth in the UK has received ethics approval and the protocol is now publicly available. The full trial protocol can now be found on the website of King's College London (permalink here ). According to the website of the UK's ethics regulator HRA, the trial received ethics approval in early November . It is unclear whether it has also secured approval from the UK's medicines regulator MHRA. So far, the trial has not been registered on...

The UK is poised to soon launch a landmark trial of puberty blockers for transgender youth to “to find out how the [National Health Service] can best support children and young people with gender incongruence”.   The trial has already been funded with public money and has now reportedly been submitted for ethics review.   Refusal to release the trial protocol   The Health Research Authority  (HRA), the central body overseeing ethics approvals for clinical trials in the UK, has refused to make...